Anti-CDK4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Supplier: Bioss

BS-0633R-A555
10239-014EA 811.1 USD
10239-014
Anti-CDK4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Antibodies
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CDK4
Clonality: Polyclonal
Clone: 0
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity:
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