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Anti-PSEN1 Mouse Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Bioss
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1;PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Three alternative splice variants of PSEN1 have been identified.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human, Rat, Rabbit


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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-0025M-FITC 10229-536 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol PSEN1
Antigen Name Presenilin 1
Reactivity Rabbit, Rat, Human
Conjugation FITC (Fluorescein Isothiocyanate)
Clonality Polyclonal
Antibody Type Primary
Host Mouse
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms PSNL1, Alzheimer Disease 3, Senilin 1, Homo Sapiens Clone CC44 Senilin 1, FAD, S182 Protein, AD3, PS1
Gene ID 5663
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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