Anti-PSEN1 Rabbit Polyclonal Antibody (Cy5®)

Supplier: Bioss

BS-0024R-CY5
10229-506EA 810.86 USD
10229-506
Anti-PSEN1 Rabbit Polyclonal Antibody (Cy5®)
Antibodies
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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