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Anti-PSEN1 Mouse Polyclonal Antibody

Supplier: Bioss

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human, Rat, Rabbit




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-0024M 10229-412 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Presenilin 1
Antigen Symbol PSEN1
Antigen Synonyms S182 Protein, PSNL1, PS1, Senilin 1, FAD, Alzheimer Disease 3, AD3, Homo Sapiens Clone CC44 Senilin 1
Clonality Polyclonal
Concentration 1 μg/μl
Conjugation Unconjugated
Cross Adsorption No
Form liquid
Gene ID 29192
Host Mouse
ImmunoChemistry Yes
Immunogen 1-50/467
Isotype IgG
Purification Purified by Protein A
Reactivity Rat, Rabbit, Human
Shipping Temperature 4°C
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage Temperature Store at -20°C for 12 months
Western Blot Yes
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