DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX41, also known as Abstrakt, interacts with and regulates the expression of sorting nexin-2 (SNX2), a protein involved in protein sorting in the trans-Golgi network. Recent evidence suggests that DDX41 also plays a role in the innate immune response by sensing intracellular viral DNA, triggering TBK1 and IRF3 activation, leading to a type I interferon immune response.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: User Optimized; Immunofluorescence Microscopy: User Optimized; Western Blot: 1-2 μg/mL; contains 0.02% (w/v) Sodium Azide
Reactivity: Human, Mouse, Rat