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Anti-TNFRSF10C Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals

Anti-DCR1 antibody 100 µg

Anti-DCR1 antibody 100 µg

600-401-AT5

10800-992EA 518.29 USD

10800-992

Anti-TNFRSF10C Rabbit Polyclonal Antibody

Antibodies

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Recommended Dilutions: ELISA: 1:5,000; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 0.5 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: TNFRSF10C
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Extracellular
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat

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