Anti-DACT2 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals
600-401-AS0
10801-080EA 518.29 USD
10801-080
Anti-DACT2 Rabbit Polyclonal Antibody
Antibodies
The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: 2.5 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: DACT2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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