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Anti-CDIP1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals

CDIP antibody 100 µg

CDIP antibody 100 µg

600-401-AJ6

10802-296EA 518.29 USD

10802-296

Anti-CDIP1 Rabbit Polyclonal Antibody

Antibodies

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

Recommended Dilutions: ELISA: 1:2500-1:5000; Immunohistochemsitry: 2.5 µg/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 0.25-0.5 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: CDIP1
Clonality: Polyclonal
Clone: 0
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity:

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