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Anti-CBL Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals

Anti-CBL Rabbit polyclonal antibody

Anti-CBL Rabbit polyclonal antibody

600-401-AE8

10800-618EA 518.29 USD

10800-618

Anti-CBL Rabbit Polyclonal Antibody

Antibodies

The mammalian cbl family of ubiquitin ligases consists of three homologs known as cbl (also known as c-Cbl), Cbl-B, and Cbl-3 which share highly conserved a tyrosine-kinase-binding domain, linker and RING finger domain in their amino-terminal halves. Similar to other E3 ubiquitin ligases, Cbl catalyzes the transfer of ubiquitin from an E2 or Ubc (ubiquitin-conjugating) enzyme to the e-amino group of a lysine residue of the substrate protein. Cbl acts to negatively regulate many types of cell-surface receptors, including the Syk protein tyrosine kinase family. Cbl is thought to be involved in T- and B-cell signaling, in addition to thymus development. Of the three known homologs in the cbl family, cbl antibody reacts specifically with cbl. Multiple isoforms of cbl have been reported.

Recommended Dilutions: ELISA: 1:5000-1:20,000; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 0.5-2 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: CBL
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat

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