The calcium-sensing receptor protein (CASR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (1). It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis (1). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (1,2). Recent evidence suggests that activated CASR contributes to the cytokine secretion through the partial MAPK and NF-kappaB pathways in T cells (3).
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 5 µg/mL; Immunofluorescence Microscopy: 20 μg/mL; Western Blot: 1-2 μg/mL; contains 0.02% (w/v) Sodium Azide
Reactivity: Human, Mouse, Rat