Anti-CARD10 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals
600-401-AC0
10800-534EA 518.29 USD
10800-534
Anti-CARD10 Rabbit Polyclonal Antibody
Antibodies
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.

Recommended Dilutions: ELISA: User Optimized; Immunohistochemsitry: 5 µg/mL ; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: CARD10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human
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