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Anti-ATG5 Chicken Polyclonal Antibody

Supplier: Rockland Immunochemicals

ATG5 N-term antibody 100 µg

ATG5 N-term antibody 100 µg

200-901-Y86 200-901-Y86

10800-216EA 518.29 USD

10800-216 CA10800-216

Anti-ATG5 Chicken Polyclonal Antibody

Antibodies

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells.

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 2.5 ?g/mL; Western Blot: 1 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: ATG5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Chicken
Isotype:
Reactivity: Human, Mouse, Rat

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