Anti-BID Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals
200-401-Z66
10800-358EA 518.29 USD
10800-358
Anti-BID Rabbit Polyclonal Antibody
Antibodies
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals, exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein. The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize.

Recommended Dilutions: ELISA: 1:5000-1:20,000; Western Blot: 0.5 - 2 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: BID
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity: Human, Mouse
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