Anti-AKT3 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals
200-401-N98S 200-401-N98S
10799-682EA 147.5 USD
CA10799-682 10799-682
Anti-AKT3 Rabbit Polyclonal Antibody
Antibodies
AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as AKT1, Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. Anti-AKT Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience, Signal Transduction research.

Recommended Dilutions: ELISA: User Optimized; Flow Cytometry: User Optimized; Immunohistochemsitry: User optimized; Western Blot: 1:1,000 - 1:5,000; contains 0.01% (w/v) Sodium Azide

Type: Primary
Antigen: AKT3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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