Anti-GAB1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals
200-401-G66 200-401-G66
10801-866EA 518.16 USD
CA10801-866 10801-866
Anti-GAB1 Rabbit Polyclonal Antibody
Antibodies
GAB1 antibody detects GAB1 which is a member of the IRS1-like multisubstrate docking protein family. The protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. GAB1 plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. It is known to play a role in FGFR1 signaling and is probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). GAB1 interacts with GRB2 and with other SH2-containing proteins. It is known to interact with phosphorylated LAT2, PTPRJ, FRS2, GRB2, PIK3R1 and SOS1. GAB1 gets phosphorylated in response to FGFR1 activation. This tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Anti-GAB1 Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience and Signal Transduction research.

Recommended Dilutions: ELISA: 1:2,000 - 1:10,000; Western Blot: 1:500-1:2000; contains 0.01% (w/v) Sodium Azide

Type: Primary
Antigen: GAB1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
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