Anti-FIG4 Mouse Monoclonal Antibody (ATTO 594) [clone: S202-7]

Supplier: Rockland Immunochemicals
200-355-W80
10801-404EA 464.71 USD
10801-404
Anti-FIG4 Mouse Monoclonal Antibody (ATTO 594) [clone: S202-7]
Fig4/Sac3 phosphatase, a 97-kDa protein, specifically removes the 5-phosphate from the inositol ring of PI(3,5)P2, a membrane-bound phospholipid, which acts as a molecular signal for trafficking and fusion of intracellular vesicles. It is broadly expressed in all eukaryotic cells and plays a vital role in intracellular membrane trafficking and signaling. Mutations in Fig4/Sac3 have been linked to pale tremor mice that exhibit neuropathy with severe central and peripheral neuronal degeneration, including the loss of neurons in the dorsal root ganglion and the sciatic nerve. Fig4/Sac3 knockout mice have been shown to be smaller in size and exhibit abnormal tremor and gait and neuronal autophagy. Anti-Fig4/Sac3 is ideal for research in Neuroscience and Cell Signaling.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: User Optimized; Western Blot: 1:1000; 0.1% (w/v) Sodium Azide

Type: Primary
Antigen: Sac3
Clonality: Monoclonal
Clone: S202-7
Conjugation: ATTO 594
Epitope: C-terminal
Host: Mouse
Isotype:
Reactivity: Human, Rat, Mouse
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