Anti-ATF4 Mouse Monoclonal Antibody (AP (Alkaline Phosphatase)) [clone: S360A-24]

Supplier: Rockland Immunochemicals
200-305-W61 200-305-W61
10801-954EA 538.68 USD
CA10801-954 10801-954
Anti-ATF4 Mouse Monoclonal Antibody (AP (Alkaline Phosphatase)) [clone: S360A-24]
Antibodies
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation. Anti-ATF4 is ideal for researchers interested in Cell Signaling, Oncology, Cell Differentiation, and Apoptosis; relevant pathways include MAPK signaling pathways, Activation of cAMP-Dependent PKA, CREB pathways, GPCR pathways and Rho Family GTPases.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: User Optimized; Western Blot: 1:1000; 0.1% (w/v) Sodium Azide

Type: Primary
Antigen: ATF4
Clonality: Monoclonal
Clone: S360A-24
Conjugation: AP (Alkaline Phosphatase)
Epitope: C-Terminal
Host: Mouse
Isotype:
Reactivity: Human, Rat
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