Anti-ENDOG Mouse Monoclonal Antibody [clone: 7G1C10]

Supplier: Rockland Immunochemicals
200-301-BA8
10802-618EA 528.48 USD
10802-618
Anti-ENDOG Mouse Monoclonal Antibody [clone: 7G1C10]
Antibodies
The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans . EndoG also cleaves DNA in vitro.

Recommended Dilutions: ELISA: 1:50,000-1:100,000; Western Blot: 2.5-5 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: ENDOG
Clonality: Monoclonal
Clone: 7G1C10
Conjugation: Unconjugated
Epitope: Center
Host: Mouse
Isotype:
Reactivity: Human, Mouse, Rat
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