Anti-Tau-13 Mouse Monoclonal Antibody [clone: B11E8]

Supplier: BioVision
3453-100
10003-992EA 420.29 USD
10003-992
Anti-Tau-13 Mouse Monoclonal Antibody [clone: B11E8]
Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thoμght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.

Recommended Dilutions: Western Blot: 1:1000; Immunoprecipitation: 1:500; and Immunohistochemistry: 1:100

Type: Primary
Antigen: Tau-13
Clonality: Monoclonal
Clone: B11E8
Conjugation: Unconjugated
Epitope: N-terminal
Host: Mouse
Isotype: IgG1
Reactivity: Human
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