Anti-TLR1 Goat Polyclonal Antibody

Supplier: BioVision
3446-100
10003-970EA 309.39 USD
10003-970
Anti-TLR1 Goat Polyclonal Antibody
The TLR (toll-like receptors) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFκB and sμggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater that 65% sequence identity, and, like other members of TLR family, it induces NFκB signaling upon activation.

Recommended Dilutions: Western Blot: 1:200-1000; ELISA: 1:100-500

Type: Primary
Antigen: TLR1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Goat
Isotype: IgG
Reactivity: Human
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