Anti-BAG4 Rabbit Polyclonal Antibody

Supplier: BioVision
3221-100
10003-564EA 309.39 USD
10003-564
Anti-BAG4 Rabbit Polyclonal Antibody
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family throμgh their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules throμgh the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domain. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Recommended Dilutions: Western Blot: 1-2 µg/ml

Type: Primary
Antigen: BAG4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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