Anti-APP Rabbit Polyclonal Antibody

Supplier: BioVision
5045-100
10007-448EA 379.44 USD
10007-448
Anti-APP Rabbit Polyclonal Antibody
Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease.

  • Recommended Dilutions: Immunohistochemistry: 2 μg/ml; Western Blot: 1-2 μg/ml; ELISA

Type: Primary
Antigen: APP
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat
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