Anti-UCHL5 Chicken Polyclonal Antibody

Supplier: BioVision
6129-50
10008-194EA 169.28 USD
10008-194
Anti-UCHL5 Chicken Polyclonal Antibody
Protein ubiquitination and deubiquitination are reversible processes catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (DUBs). DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. UCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all possess a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL5 and BAP1 have unique extended C-terminal tails. UCHL5 is the only ubiquitin carboxy-terminal hydrolase (UCH)-family protease that is associated with mammalian proteasomes. It is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. It is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regulatory complex.

Recommended Dilutions: Western Blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 ?g/mL

Type: Primary
Antigen: UCHL5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Chicken
Isotype: IgG
Reactivity: Human
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