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Anti-Dnmt2 Rabbit Polyclonal Antibody

Supplier: BioVision

Anti-Dnmt2 Rabbit Polyclonal Antibody

Anti-Dnmt2 Rabbit Polyclonal Antibody

3488-100

10004-128EA 309.39 USD

10004-128

Anti-Dnmt2 Rabbit Polyclonal Antibody

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml; immunofluorescence

Type: Primary
Antigen: Dnmt2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse

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