Anti-PARP1 Rabbit Polyclonal Antibody

Supplier: BioVision
3140-100
10003-446EA 449.49 USD
10003-446
Anti-PARP1 Rabbit Polyclonal Antibody
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml; Immunocytochemistry: 10-20 µg/ml

Type: Primary
Antigen: PARP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype: IgG
Reactivity: Human
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