Anti-CALR Rabbit Polyclonal Antibody

Supplier: BioVision
AB18847-100
10003-320EA 360.69 USD
10003-320
Anti-CALR Rabbit Polyclonal Antibody
Antibodies
Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies sμggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also sμggest its involvement in certain autoimmune diseases. Consistence with its multiple functions the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.

Recommended Dilutions: Western Blot: 0.5-4 µg/ml; in Immunohistochemistry: 10-20 µg/ml

Type: Primary
Antigen: CALR
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat
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