The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
Type: Primary
Antigen: Ifng
Clonality: Monoclonal
Clone: XMG1.2
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: Rat IgG1, kappa
Reactivity: Mouse