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Anti-Ctla4 Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: UC10-4F10-11]

Supplier: ProSci

76-856

10764-956EA 297.25 USD

10764-956

Anti-Ctla4 Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: UC10-4F10-11]

Antibodies

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

Type: Primary
Antigen: Ctla4
Clonality: Monoclonal
Clone: UC10-4F10-11
Conjugation: APC
Epitope:
Host: Hamster
Isotype: Armenian Hamster IgG
Reactivity: Mouse

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