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Anti-CD80 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 2D10.4]

Supplier: ProSci

76-037

10766-174EA 302.92 USD

10766-174

Anti-CD80 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 2D10.4]

Antibodies

The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Type: Primary
Antigen: CD80
Clonality: Monoclonal
Clone: 2D10.4
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: Mouse IgG1, kappa
Reactivity: Human

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