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Anti-SELL Rat Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: MEL-14]

Supplier: ProSci

76-200

10766-348EA 375.62 USD

10766-348

Anti-SELL Rat Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: MEL-14]

Antibodies

The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains. The weight of the CD62L molecules depend on their origin, 74 kDa on lymphocytes or 95 kDa on neutrophils. In the mouse organism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils. The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins (MadCAM-1, GLYCAM-1, and CD 34). It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes. After cell activation, it is quickly shed by neutrophils and lymphocytes.

Type: Primary
Antigen: Sell
Clonality: Monoclonal
Clone: MEL-14
Conjugation: FITC
Epitope:
Host: Rat
Isotype: Rat IgG2a, kappa
Reactivity: Mouse

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