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Anti-FNBP1L Rabbit Polyclonal Antibody

Supplier: ProSci

Western blot analysis of TOCA-1 in human brain tissue lysate in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 0.5 ug/mL.

Immunohistochemical staining of human brain tissue using TOCA-1 antibody at 2.5 µg/ml.

Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 µg/ml.

Western blot analysis of TOCA-1 in human brain tissue lysate in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 0.5 ug/mL.

Immunohistochemical staining of human brain tissue using TOCA-1 antibody at 2.5 µg/ml.

Immunofluorescence of TOCA-1 in Human Brain cells with TOCA-1 antibody at 20 µg/ml.

4375_S

10750-012EA 179.85 USD

10750-012

Anti-FNBP1L Rabbit Polyclonal Antibody

Antibodies

TOCA-1 Antibody: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.

Type: Primary
Antigen: FNBP1L
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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