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DAPT ≥98% (by TLC)

DAPT ≥98% (by TLC)

DAPT ≥98% (by TLC)

Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester , tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate , (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester , (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

1855-5

10188-316EA 220.57 USD

10188-316

DAPT ≥98% (by TLC)

DAPT

Cell permeable. A potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

Appearance: White to off-white solid

Formula: C₂₃H₂₆F₂N₂O₄
MW: 432.47 g/mol
Storage Temperature: Freezer

MDL Number: MFCD04974585
CAS Number: 208255-80-5

Specification Test Results

CAS	208255-80-5
Purity	≥98% by TLC
Form	White to off-white solid

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