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Canertinib dihydrochloride ≥99%

Supplier: BioVision

Canertinib dihydrochloride ≥99%

Canertinib dihydrochloride ≥99%

Synonyms: CI-1033 , N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride , PD-183805

AB141402-50MG AB141402-5MG

10187-740EA 789.07 USD

10187-740 10187-738

Canertinib dihydrochloride ≥99%

Canertinib dihydrochloride

Canertinib is an irreversible tyrosine kinase inhibitor. It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.

Formula: C₂₄H₂₅ClFN₅O₃·2HCl
MW: 558.86 g/mol
Storage Temperature: Freezer

MDL Number: MFCD09954112
CAS Number: 289499-45-2

Specification Test Results

CAS	289499-45-2
Purity	≥99%
Form	Off-white to pale green solid

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