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Anti-KNGP Mouse Monoclonal Antibody [clone: 24F9]

Supplier: Young In Frontier
LF-MA0204
Kininogens are precursors for kinin, and the two main types of them are high-molecular weight kininogen (HMWK) and low-molecular weight kininogen (LMWK). HMWK also known as the Williams-Fitzgerald-Flaujeac factor is a protein from the blood coagulation system as well as the kinin-kallikrein system. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. LMWK is produced locally by numerous tissues, and secreted together with tissue kallikrein.
Kininogens are synthesized in the liver and circulate in the plasma and other body fluids.
The kinins are pharmacologically active polypeptides released in the tissues and body fluids as a result of the enzymatic action of kallikreins on kininogens. The kinin family includes bradykinin (BK) (Arg-Pro-Pro-gly-Phe-Ser-Pro-Phe-Arg), kallidin (Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) and methionyl-lysyl-BK (Met-Lys-Arg-Pro-Pro-Gly-Phe-Arg). Kallidin and methionyl-lysyl-BK are converted into BK by aminopeptidases present in plasma and urine. Active tissue kallikrein acts on LMWK to release kallidin. The plasma kallikrein is found in circulation in an inactive form, which is known as prekallikrein or Fletcher factor.
BK and kallidin act through activation of G-protein-coupled constitutive B(2) or inducible kinin B(1) receptors linked to signaling pathways involving increased intracellular Ca concentrations and/or release of mediators including arachidonic acid metabolites, NO and EDHF (Endothelium-derived hyperpolarizing factor). In the cardiovascular system, the kallikrein-kinin system exerts a fine control of vascular smooth muscle tone and arterial blood pressure, and plays a significant cardioprotective effect.

Western Blot: 0.5 μg/ml;

Type: Primary
Antigen: KNGP
Clonality: Monoclonal
Clone: 24F9
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0204 10219-228 Each (100µl) Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol KNGP
Antigen Name Kininogen Precursor
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 24F9
Host Mouse
Isotype IgG
Western Blot Yes
ELISA Yes
Concentration 1 mg/ml
Cross Adsorption none
Immunogen Protein purified from Human plasma
Purification Protein G purified
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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