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Anti-IKBKB Mouse Monoclonal Antibody [clone: 42D1]

Supplier: Young In Frontier
IκB kinase β (IKKβ) is a component of a multiprotein kinase complex that regulates the activity of the transcription factor NF-κB. Activation of the IKK complex via upstream stimuli leads to phosphorylation and degradation of NF-κB bound IκB (Inhibitor of κB). Subsequently, free NF-κB dimers enter the nucleus and regulate the transcription of a variety of target genes involved in cell proliferation and differentiation, apoptosis, and inflammation, etc. The IKK complex consists of 2 highly homologous kinase subunits, IKKα and IKKβ, and a nonenzymatic regulatory component, IKKγ/NEMO. The relative contributions of IKKα and IKKβ to the signaling complex vary according to the requirements of the cell. IKKβ plays a predominant role in immune responses, while IKKα alone appears to be sufficient for at least some developmental systems. Recently, IKK/NF-κB signaling pathway was studied as therapeutic targets in cancer.

Western Blot: 1.0 μg/ml;

Type: Primary
Antigen: IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta)
Clonality: Monoclonal
Clone: 42D1
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG2b Kappa
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0192 10219-204 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol IKBKB (inhibitor of kappa light Polypeptide gene enhancer in B-cells, kinase beta)
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 42D1
Host Mouse
Isotype IgG2b
Western Blot Yes
Concentration 1 mg/ml
Cross Adsorption none
Immunogen Recombinant human protein purified from E.coli (His-IKKbeta)
Purification Protein G purified
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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