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Anti-PTPN11 Mouse Monoclonal Antibody [clone: 5F2]

Supplier: Young In Frontier
LF-MA0186
SHP2 is a tyrosine phosphatase containing two tandem SH2 (src homology 2) domains. Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules.
SHP1 and SHP2 represent a subfamily of non-transmembrane PTPs that contain two SH2 domains followed by a PTP domain. Tyrosine phosphorylation of SHP2 is required for normal ERK activation in response to some growth factors. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. This auto-inhibition is relieved by the binding of phosphopeptides to SH2 domain, resulting in activation of phostphatase activity.
Noonan syndrome characterized by an abnormal face, short stature and cardiac abnormalities is due to the mutations of N-terminal SH2 domain or PTP domain. SHP2 mutations might also cause some leukemia, and could be important in pathogenesis by Helicobacter pylori, the major cause of gastric ulcer and carcinoma.

Western Blot: 1:2,000; Immunoprecipitation: 1 μl;

Type: Primary
Antigen: PTPN11
Clonality: Monoclonal
Clone: 5F2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0186 10219-192 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol PTPN11
Antigen Name Protein Tyrosine Phosphatase, Non-receptor Type 11
Reactivity Human, Rat, Mouse
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 5F2
Host Mouse
Isotype IgG1
Western Blot Yes
ImmunoPrecipitation Yes
Antigen Synonyms PTP2C, NS1, PTP-1D, SH-PTP2, CFC, SHP2, METCDS, JMML, SH-PTP3, BPTP3
Cross Adsorption none
Immunogen Recombinant human GST-SHP2 protein purified from E.coli
Purification Ammonium sulfate precipitation
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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