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Anti-HES1 Mouse Monoclonal Antibody [clone: 7H11]

Supplier: Young In Frontier
LF-MA0184
The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and β-cells.
Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

Western Blot: 1:500~1,000; Immunoprecipitation: 1 μl;

Type: Primary
Antigen: HES1
Clonality: Monoclonal
Clone: 7H11
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0184 10219-188 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol HES1
Antigen Name Hairy and enhancer of split 1
Reactivity Human, Rat, Mouse
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 7H11
Host Mouse
Isotype IgG2b
Western Blot Yes
ELISA Yes
ImmunoPrecipitation Yes
Antigen Synonyms Hairy-like, Transcription factor HES-1, HRY, Hairy and enhancer of split 1, HL, HHL, Hairy homolog
Cross Adsorption none
Immunogen His-tagged recombinant human Hes1 protein purified from E.coli
Purification Ammonium sulfate precipitation
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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