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Anti-TTR Mouse Monoclonal Antibody [clone: 100]

Supplier: Young In Frontier
LF-MA0174
Transthyretin (TTR, 55 kDa homotetramer) is a thyroid hormone-binding protein that transports thyroxine (T4) from the bloodstream to the brain. TTR was originally called prealbumin because it ran faster than albumin on electrophoresis gels. . TTR is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine. TTR is suggested that plays an essential role in brain function. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC).

Western Blot: 1.0 μg/ml; Immunoprecipitation: 2.0 μg;

Type: Primary
Antigen: TTR
Clonality: Monoclonal
Clone: 100
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0174 10219-168 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol TTR
Antigen Name Transthyretin
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 10E1
Host Mouse
Isotype IgG2a
Western Blot Yes
ImmunoPrecipitation Yes
Antigen Synonyms CTS, CTS1, HEL111, ATTR, TBPA, Transthyretin, HsT2651, PALB
Concentration 1 mg/ml
Cross Adsorption none
Immunogen Recombinant human protein purified from E.coli
Purification Protein G purified
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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