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Anti-RBR1 Mouse Monoclonal Antibody [clone: 7000000]

Supplier: Young In Frontier
LF-MA0172
The Rb protein (pRb, 110kDa) is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. pRb is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. pRb prevents the cell from replicating damaged DNA by preventing its progression through the cell cycle into its S phase or progressing through G1 phase. pRb can actively inhibit cell cycle progression when it is dephosphorylated while this function is inactivated when pRb is phosphorylated. pRb is activated near the end of mitosis (M phase) when a phosphatase dephosphorylates it, allowing it to bind E2F. The pRb protein represses gene transcription, required for transition from G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the promoter of these genes as a complex with E2F.

Western Blot: 0.5 μg/ml; Immunoprecipitation: 2.0 μg;

Type: Primary
Antigen: RBR1
Clonality: Monoclonal
Clone: 7000000
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0172 10219-164 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol RBR1
Antigen Name Retinoblastoma-related Protein 1
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 7E6
Host Mouse
Isotype IgG1
Western Blot Yes
ELISA Yes
ImmunoPrecipitation Yes
Concentration 1 mg/ml
Cross Adsorption none
Immunogen Recombinant human protein purified from E.coli
Purification Protein G purified
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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