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Anti-APP Mouse Monoclonal Antibody [clone: 32A1]

Supplier: Young In Frontier
Amyloid β (Aβ or A β) is a protein fragment of 39-43 amino acids that is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Aβ is formed after sequential cleavage of the amyloid precursor protein (APP, transmembrane glycoprotein) by the β- and γ-secretases. . The major species generated are Aβ40 and Aβ42. The latter is more hydrophobic and more apt to aggregate and thus is considered to be primarily pathogenic, consistent with the phenotype of the major familial AD-causing mutations. Increases in either total Aβ levels or the relative concentration of the 42-amino acid form have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. The 42-mers are the most amyloidogenic form of the peptide.

Western Blot: 1:2,000;

Type: Primary
Antigen: APP
Clonality: Monoclonal
Clone: 32A1
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG2b
Reactivity: Human



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0152 10219-124 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

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* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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Antigen Symbol APP
Antigen Name Amyloid beta (A4) Precursor Protein
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 32A1
Host Mouse
Isotype IgG2b
Western Blot Yes
Antigen Synonyms PN-II, CVAP, AAA, CTFgamma, ABPP, APPI, AD1, PN2, ABETA
Cross Adsorption none
Immunogen Synthetic peptide
Purification Ammonium sulfate precipitation
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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