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Anti-APP Mouse Monoclonal Antibody [clone: 32A1]

Supplier: Young In Frontier
LF-MA0152
Amyloid β (Aβ or A β) is a protein fragment of 39-43 amino acids that is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Aβ is formed after sequential cleavage of the amyloid precursor protein (APP, transmembrane glycoprotein) by the β- and γ-secretases. . The major species generated are Aβ40 and Aβ42. The latter is more hydrophobic and more apt to aggregate and thus is considered to be primarily pathogenic, consistent with the phenotype of the major familial AD-causing mutations. Increases in either total Aβ levels or the relative concentration of the 42-amino acid form have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. The 42-mers are the most amyloidogenic form of the peptide.

Western Blot: 1:2,000;

Type: Primary
Antigen: APP
Clonality: Monoclonal
Clone: 32A1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0152 10219-124 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol APP
Antigen Name Amyloid beta (A4) Precursor Protein
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 32A1
Host Mouse
Isotype IgG2b
Western Blot Yes
ELISA Yes
Antigen Synonyms PN-II, CVAP, AAA, CTFgamma, ABPP, APPI, AD1, PN2, ABETA
Cross Adsorption none
Immunogen Synthetic peptide
Purification Ammonium sulfate precipitation
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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