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Anti-TXN Mouse Monoclonal Antibody [clone: 3A1]

Supplier: Young In Frontier
LF-MA0055
The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 – 58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena (1).

Western Blot: 1:2000; Immunoprecipitation Immunohistochemistry: Paraffin-embedded sections;

Type: Primary
Antigen: TXN
Clonality: Monoclonal
Clone: 3A1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL LF-MA0055 10219-046 Each (100µl) Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol TXN
Antigen Name Thioredoxin
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone 3A1
Host Mouse
Isotype IgG2b
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
Antigen Synonyms TRX, TRDX, TRX1
Cross Adsorption none
Immunogen Recombinant human protein purified from E.coli
Purification Ammonium sulfate precipitation
Storage Temperature Store for 1 year at -20°C from date of shipment
Shipping Temperature Ice
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