Human Recombinant STNF R TYPE II (from E. coli)

Supplier: Tonbo Biosciences
21-7084-U020 21-7084-U500 21-7084-U005 21-7084-U100
10274-020EA 1931.93 USD
10274-020 10002-424 10274-016 10274-018
Human Recombinant STNF R TYPE II (from E. coli)
TNF receptor II (TNFRII or TNFRSF1B), along with the structurally related TNFRI, belong to the TNF receptor superfamily of proteins. TNFRII has a more restricted expression pattern than TNFRI, limited mainly to hematopoietic and immune system cells, whereas TNFRI is thought to be present on all cell types. TNFRII is a high-affinity receptor for TNF-alpha and also binds TNF-beta, but at a lower affinity. Binding to membrane-bound TNF results in effective activation, but while soluble TNF binds to TNFRII, it does not activate its signaling pathway. Signaling through this receptor regulates various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. The soluble form of TNFRII is capable of inhibiting TNF-alpha-induced activities by acting as a decoy receptor, thereby reducing the inflammatory response.

  • Carrier-free
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR