Toluene-α-sulfonyl fluoride, white to off white needle crystals

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Synonyms: α-Toluenesulfonyl fluorideα-Toluenesulphonyl fluoridePMSFPhenylmethylsulfonyl fluoridePhenylmethylsulphonyl fluoridePhenylmethanesulfonyl fluoridePhenylmethanesulphonyl fluoride

0219538180 0219538125 0219538101 02195381.2 0219538105
IC19538180EA 1042.56 USD
IC19538180 IC19538101 IC19538125 IC195381.2 IC19538105
Toluene-α-sulfonyl fluoride, white to off white needle crystals
Toluene-α-sulphonyl fluoride

Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Inhibits mammalian acetyl cholinesterase, but not those from fish sources.


  • Presentation: White to off white needle crystals
  • Causes sulfonylation of the active-site serine residue
  • A less toxic substitute for the extremely toxic diisopropylfluorophosphate


Phenylmethylsulfonyl fluoride inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase.
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.


Soluble in methanol and ethanol

Formula: C₇H₇FO₂S
MW: 174.2 g/mol
Melting Pt: 89…99 °C
Storage Temperature: Refrigerator
MDL Number: MFCD00007424
CAS Number: 329-98-6
UN: 2928
ADR: 6.1,II
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