3-Isobutyl-1-methylxanthine, white powder

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Warning

Synonyms: 2,6-Dihydroxy-3-isobutyl-1-methylpurine3,7-Dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione

0219526205 02195262.1 0219526201 02195262.2
IC19526205EA 1124.53 USD
IC19526205 IC19526201 IC195262.2 IC195262.1
3-Isobutyl-1-methylxanthine, white powder
3-Isobutyl-1-methylxanthine

IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.


IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.


Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/mL or 25 mg/mL with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9.5); slightly soluble in water (0.3 mg/mL hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3.2 mg/mL.


Caution: Research Use Only (RUO).

Formula: C₁₀H₁₄N₄O₂
MW: 222.25 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00005584
CAS Number: 28822-58-4

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Specification Test Results

Identity Test Passes
FTIR Conforms to Standard
Melting Point 195 - 202 °C

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