Amphotericin B (from Streptomyces species), yellow powder

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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IC19504380EA 77.03 USD
IC19504380 IC19504383 IC19504390
Amphotericin B (from Streptomyces species), yellow powder
Amphotericin B

Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death.


  • Potency: >800 µg/mg


Antimicrobial spectrum: fungi and yeast. Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast


Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers. It is also commonly used in tissue culture as an antifungal supplement.


Soluble in acidic water (pH 2) or basic water (pH 11) (about 0,1 mg/ml). Water solubility can be increased with the addition of deoxycholic acid, sodium salt (increasing solubility with increasing concentration of deoxycholic acid). Soluble in Dimethylformamide (DMF) (2 to 4 mg/ml), DMF + 1 M HCl (3:1) (60 to 80 mg/ml), DMSO (30 to 40 mg/ml), propylene glycol; slightly soluble in methanol and methyl alcohol; insoluble in water, anhydrous alcohol, ether, benzene, and toluene.

Formula: C₄₇H₇₃NO₁₇
MW: 924.08 g/mol
Melting Pt: >170 °C (lit.)
Storage Temperature: Refrigerator
MDL Number: MFCD00877763
CAS Number: 1397-89-3
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Specification Test Results

Identity Test Passes
Potency ≥800 µg/mg
Source Streptomyces sp.
Expiration Date Month/Day/Year

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