Clozapine, yellow powder

Supplier: MP BIOMEDICALS (FKA ICN BIOMED

Synonyms: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

0215976005 0215976050
IC15976050EA 177.58 USD
IC15976050 IC15976005
Clozapine, yellow powder
Clozapine

Clozapine is a dibenzodiazepine compound, structurally related to loxapine is used in cell signaling research. It is an a typical antipsychotic medication used in the treatment of schizophrenia. It is a dopamine D4 and D2 receptor antagonist which has high affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM). It is also a potent, selective muscarinic antagonist which exhibits the highest reported affinity for 5-HT1A and 5-HT1C sites.


Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.


Soluble in 0,1 M HC1 (25 mg/ml) or DMSO (100 mM).

Formula: C₁₈H₁₉ClN₄
MW: 326.83 g/mol
Melting Pt: 182…184 °C (lit.)
Storage Temperature: Ambient
MDL Number: MFCD00153785
CAS Number: 5786-21-0

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