Ketoconazole ≥98%, white powder



Synonyms: (+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

0215915880 0215915890 0215915850
IC15915880EA 142.45 USD InStock
IC15915880 IC15915890 IC15915850
Ketoconazole ≥98%, white powder

Ketoconazole is an antifungal agent; Cytochrome P450 inhibitor and demonstrates anti-psoriatic activity. A liver cytochrome responsible for the metabolism of many drug substrates in humans.

Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.

Ketoconazole as an Antifungal agent, interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .

Soluble in DMSO or chloroform.

Formula: C₂₆H₂₈Cl₂N₄O₄
MW: 531.43 g/mol
Storage Temperature: Ambient
MDL Number: MFCD00058579
CAS Number: 65277-42-1
UN: 2811
ADR: 6.1,III

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Specification Test Results

Identity Test Passes
Purity ≥98%
FTIR Conforms to Standard
Melting Point 145 - 152 °C

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