Brefeldin A ≥98%

Supplier: MP BIOMEDICALS (FKA ICN BIOMED

Synonyms: Brefeldin A, natural

0215902705 0215902725
IC15902705EA 180.41 USD
IC15902705 IC15902725
Brefeldin A ≥98%
Brefeldin A

Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. BFA inhibits protein synthesis in cultured cells and inhibits the transport of secretory and lysosomal proteins at concentrations of 1-10 µg/mL. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.


Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.


Soluble in methanol - clear colorless solution at 5mg/mL Soluble in chloride, methylene, ethanol (5 mg/mL-clear, colorless solution), methanol (5 mg/mL - clear, colorles solution), or DMSO (20 mg/mL).


Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. BFA inhibits protein synthesis in cultured cells and inhibits the transport of secretory and lysosomal proteins at concentrations of 1-10 µg/mL. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.

Formula: C₁₆H₂₄O₄
MW: 280.4 g/mol
MDL Number: MFCD00083258
CAS Number: 20350-15-6
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