ICNA02157805

0215780580 0215780525
IC15780525EA 381.24 USD
IC15780525 IC15780580
ICNA02157805
1,1-Dimethylbiguanide hydrochloride (Metformin) is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

1,1-Dimethylbiguanide Hydrochloride has various medical uses such as in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics.

Soluble in water (100 mg/ml - clear, colorless solution), 95% ethanol; insoluble in ether, acetone or chloroform.
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