ICNA02156518

0215651880 0215651883 0215651890
IC15651880EA 76.09 USD
IC15651880 IC15651883 IC15651890
ICNA02156518
13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.

The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.

Soluble in chloroform (50 mg/mL); sparingly soluble in ether; slightly soluble in ethanol and isopropanol; practically insoluble in water.
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